The negative regulators include GTPase- activating proteins (Ras-GAPs), able to enhance the intrinsic Ras-GTPase activity, thus eliciting rapid hydrolysis of ...
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The guanine-nucleotide exchange factor (GEF) Son-of-Sevenless (SOS) plays a critical role in metazoan signaling by converting Ras•GDP (guanosine ...
In some cells, G protein-coupled receptors rely on relatives of Sos, such as Ras guanine nucleotide-releasing factor 1 (RasGRF1), also known as p140Ras-GRF or ...
The guanine nucleotide exchange factors (GEF) help RAS to release the otherwise tightly bound GDP and thereby return RAS to its activated GTP bound On-state ( ...
Promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in ...
Sep 15, 2015 · Ras activation is mediated through the binding of guanine nucleotide exchange factors of which the most important is Son of Sevenless (Sos),5 ...
Mechanistically, the Sos proteins function as enzymatic factors interacting with Ras proteins in response to upstream stimuli to promote guanine nucleotide ...
Li, A. Batzer, R. Daly, et al. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to ras signaling.
In cell signalling, Son of Sevenless (SOS) refers to a set of genes encoding guanine nucleotide exchange factors that act on the Ras subfamily of small ...
A human complementary DNA was isolated that encodes a widely expressed protein, hSos1, that is closely related to Sos, the product of the Drosophila son of ...